院士

姚新生
来源: 日期:2012-03-19 10 【字体:
 
     姚新生,男,上海市人,1934年10月生,药学博士,中国工程院院士,硕士研究生、博士生导师。现任暨南大学药学院名誉院长、中药及天然药物研究所所长。
 
    1955年7月东北药学院毕业,留校任教。1981年6月-1983年6月去日本东京大学留学,获药学博士学位。1995年当选为中国工程院院士。长期从事中药天然药物化学教学研究工作。已培养了25名博士(内1名被评为教育部2001年全国百名优秀博士)、 12名硕士、3名博士后;正在培养博士生15人、硕士生20人。先后在国内外学术杂志上发表了约200篇文章(其中,SCI收载73篇),主编出版《天然药物化学》、《有机化合物波谱解析》(高等医药院校用统编教材)及《超导核磁共振波谱解析》(研究生用参考书)。申请了29项专利,成功研制开发新药4个,获省部级以上奖励5项。曾担任国务院学位委员会药学学科评议组召集人、国家自然科学基金委中医中药学科评审组组长,现在担任国家自然科学基金委杰出青年基金评审委员、全国博士后管委会医学专家组成员、中国药学会副理事长等社会职务。
 
近五年主要科研成果
代表性论文及论著
1 Xiangjiu He, Jiankuan Li, Hao Gao, Feng Qiu, Xiangmin Cui, and Xinsheng Yao*. Four New Andrographolide Metabolites in Rats. TETRAHEDRON. 2003, 59(34):6603-6607.
2  Xiangjiu He, Jiankuan Li, Hao Gao, Feng Qiu, Ke Hu, Xiangmin Cui and Xinsheng Yao*. Identification of a rare sulfphonic acid type metabolite of andrographolide in rats. Drug Metabolism and Disposition. 2003,31(8):983-985.
3  Xiangjiu He, Jiankuan Li, Hao Gao, Feng Qiu, Xiangmin Cui and Xinsheng Yao. Six New Andrographolide Metabolites in Rats. Chem. Pharm. Bull. 2003, 51(5):586-589.
4  Liu, Hongwei; Qu, Gexia; Yao, Xinsheng, The polyphenolic constituents of Engelhardtia serrata stem bark,Pharmaceutical Biology (Lisse, Netherlands) (2003), 41(4), 305-307.
5  Liu, Hongwei; Xiong, Zhili; Li, Famei; Qu, Gexia; Kobayashi, Hisayoshi; Yao, Xinsheng,Two new pregnane glycosides from Dioscorea futschauensis R. Kunth, Chemical & Pharmaceutical Bulletin  (2003),  51(9),  1089-1091.
6 Hu, Ke; Yao, Xinsheng,.The cytotoxicity of methyl protodioscin against human cancer cell lines in vitro, Cancer Investigation  (2003),  21(3),  389-393.
7 Hu, Ke; Dong, Aijun; Kobayashi, Hisayoshi; Iwasaki, Shigeo; Yao, Xinsheng, Antifungal agents from traditional Chinese medicines against rice blast fungus Pyricularia oryzae Cavara. Plant Derived Antimycotics  (2003), 525-549.
8 He, Xiangjiu; Qiu, Feng; Shoyama, Yukihiro; Tanaka, Hiroyoki; Yao, Xinsheng. Two new steroidal saponins from Gualou-xiebai-baijiu-tang consisting of Fructus trichosanthis and Bulbus allii macrostemi. Chemical & Pharmaceutical Bulletin  (2002), 50(5), 653-655.
9 Liu H W; Hu K; Zhao Q C; Cui C B; Kobayashi H; Yao X S. Bioactive saponins from Dioscorea futschauensis. PHARMAZIE (2002 Aug), 57(8), 570-2.
10 Xiang-jiu He, Feng Qiu, Yukihiro Shoyama, Hiroyoki Tanaka and Xin-sheng Yao. The active constituents from “Gualou-xiebai- baijiu- tang” Part I: Active saponins. Journal of Asian Natural Products Research. 2002,4(3): 189-196.
11 Xiangjiu He, Feng Qiu, Xinsheng Yao. A new triterpenoid from “Gualou-xiebai-baijiu -tang” consisting of Fructus Trichosanthis and Bulbus allii Macrostemi. Chinese Chemical Letters. 2002, 13(7): 637-640.
12 Ping Shen, San-Long Wang,Xi-Kuiliu,Chong-Ren Yang,Bing Cal and Xin-Sheng Yao. A new ergostanol saponin from Dioscorea  Deltoidea Wall Var.Orbiculata  Journal of Asian Natural Products Research. 2002,4(3): 211-215.
13 Ping Sheng ,San Long WANG,Xi Kui Liu,Chong Ren Yang,Bing Cai,XinSheng Yao. A new steroidal Saponin from Dioscorea deltoidea Wall var.orbiculata. Chinese Chemical Letters. 2002 851-854.
14 LiYan Wang ,Nai Li Wang , XinSheng Yao ,Syohei Miyata,Susumu Kitanaka  Diterpenes from the Roots of Euphorbia kansui and their in Vitro Effects on the Cell Division of Xenopus. Journal of Natural Products 2002 (65) 1246-1251.
15 Cheng Bin Cui,ShaoYu Yan,Bing Cai , XinSheng Yao  Carbazole Alkaloids as new cell cycle inhibitor and apoptosis inducers from clausena dunniana levl. Journal of Asian Natural Products Research 2002 4(4). 233-241.
16 Hu, Ke; Yao, Xinsheng. Protodioscin (NSC-698 796): its spectrum of cytotoxicity against sixty human cancer cell lines in an anticancer drug screen panel. Planta Medica (2002), 68(4), 297-301.
17 Jia, Xian; Guo, Rongwei; Li, Xingshu; Yao, Xinsheng; Chan, Albert S. C. Highly enantioselective hydrogenation of enamides catalyzed by rhodium-monodentate phosphoramidite complex. Tetrahedron Letters (2002), 43(32), 5541-5544.
18 H.W.Liu, K.Hu, Q.C.Zhao, C.B.Cui, H.Kobayashi and X.S.Yao, Bioactive saponins from Dioscorea futschauensis, Pharmazie 57(2002):569-572
19 Xian Jia, Rongwei Guo, Xingshu Li, Xinsheng Yao and Albert S.C.Chan, Highly enantioselective hydrogenation of enamides catalyzed by rhodium-monodentate phosphoramidite complex, Tetrahedron Letters, 43(2002)000-000
20 Takashi Sakurai, Toshio Nishimura, Noboru Otake, Yao Xinsheng, Keiichi Abe, Mitsuhiro Zeida, Hiromichi Nagasawa and Shohei Sakuda, Assamicin I and II, Novel Tripenoid Saponins with Insulin-Like Activity from Aesculus assamica Griff., Bioorganic & Medicinal Chemistry 12(2002)807-810
21 Hu, K. Yao, X.S., Methyl protogracillin(NSC-698792): the spectrum of cytotoxicity against 60 human cancer cell lines in the National Cancer Institute’s anticancer drug screen panel, Anti-Cancer Drugs, 2001, 12(6), 541-547
22 Hong Wei LIU, Hisayoshi KOBAYASHI, Ge Xia QU, Xin Sheng YAO, A New Spirostanol Saponin from Dioscorea futshauensis, Chinese Chemical Letters, 12(7):613-616,2001
23 Lin Houwen, Yi Yanghua, Yao Xinsheng, Wu Houming, Studies on Antineoplastic Constituents from Marine Bryozoan Bugula meritina Inhabiting South China Sea(III): Isolation and Structural Elucidation of Bryostatins 10,11 and 18, MARINE SCIENCE BULLETIN, 3(1):83-90, 2001
24  Ke Hu, Aijun Dong, Qishi Sun and Xinsheng Yao, Bioactivity of 247 Traditional Chinese Medicines against Pyricularia oryzae, Pharmaceutical Biology, 2001, 39(1):47-53
25 You-Wei Zhang, Ikuo Morita, Xin-Sheng Yao and Sei-itsu Murota, Inhibitory effects of eicosapentaenoic acid on hypoxia/reoxygenatino-induced tyrosine kinase activation in human umbilical vein endothelial cells. (In review)
26赵峰,室田诚逸,森田育男,姚新生,NF-ҡB与疾病,生命科学,2001,13(1):11-13
27 De-Qiang Dou, You-Wer Zhang, Lei Zhang, Ying-Jie Chen, Xin-Sheng Yao, The Inhibitory Effects of Ginsenosides on the hypoxia/reoxygenation induced protein tyrosine kinase activation, Planta Medica, 67(2001)19-23
28林厚文, 易杨华, 姚新生, 吴厚铭, 釜野德明, 中国南海总合草苔虫抗癌活性成分研究 II 总草苔虫内酯的超强抗癌活性, 《中国海洋药物》杂志,2001年第2期(总第74期),1-3
29林厚文, 易杨华, 姚新生, 吴厚铭,中国南海总和草苔虫抗癌活性成分研究 III Bruostatin 10,11,18的分离鉴定及其体外抗肿瘤活性,中国海洋药物,2001年第4期(总第76期),1-5
30 Wang, Naili; Yao, Xinsheng; Ishii, Rie; Kitanaka, Susumu, Antiallergic agents from natural sources. 3. Structures and inhibitory effects on nitric oxide production and histamine release of five novel polyacetylene glucosides from Bidens parviflora Willd.,Chem. Pharm. Bull. (2001), 49(8), 938-942.
31 Liu, Hongwei; Yao, Xinsheng, Determination of diosgenin in Dioscorea hypoglauca Palibin by HPLC-ELSD methods, Shenyang Yaoke Daxue Xuebao (2001), 18(3), 195-197.
32 Zhang, Youwei; Dou, Deqiang; Chen, Yingjie; Yao, Xinsheng, Effect of ginsenosides from Panax ginseng on proliferation of human osteosarcoma cell U2OS. Zhongcaoyao  (2001), 32(3), 232-235.
33 Duan, Changling; Qiao, Shanyi; Wang, Naili; Zhao, Yimin; Qi, Chunhui; Yao, Xinsheng, Studies on active polysaccharides from Lycium barbarum, Yaoxue Xuebao (2001), 36(3), 196-199.
34 Liu, Hongwei; Yao, Xinsheng, Study on chemical constituents of stem bark of Engelhardtia serrata Bl. Zhongguo Yaowu Huaxue Zazhi (2001), 11(1), 51-52, 62.  1005-0108.
35 Qiu F; Ma Z Z; Xu S X; Yao X S; Che C T; Chen Y J., A pair of 24-hydroperoxyl epimeric dammarane saponins from flower-buds of Panax ginseng, J Asian Nat Prod Res (2001), 3(3), 235-40.
36 Zhang Y W; Dou D Q; Zhang L; Chen Y J; Yao X S. , Effects of ginsenosides from Panax ginseng on cell-to-cell communication function mediated by gap junctions, PLANTA MEDICA (2001 Jul), 67(5), 417-22.
37 Dou D Q; Zhang Y W; Zhang L; Chen Y J; Yao X S., The inhibitory effects of ginsenosides on protein tyrosine kinase activated by hypoxia/reoxygenation in cultured human umbilical vein endothelial cells, PLANTA MEDICA (2001 Feb), 67(1), 19-23.
38  He, Xiangjiu; Yao, Xinsheng, The proceeding of chemical constituents and pharmacological activities of Opuntia, Tianran Chanwu Yanjiu Yu Kaifa (2000), 12(6), 79-83.
39  Wu, Bo; Cao, Hong; Chen, Siwei; Wang, Minwei; Yao, Xinsheng, Protective effect of extract of Fructus Trichosanthes on hypoxia and myocardial ischemia and reperfusion injury.  Shenyang Yaoke Daxue Xuebao, (2000), 17(6), 450-451, 465. 
40  Zhao, Feng; Zhang, Mengjia; Yao, Xinsheng, Determination of total alkaloid in the seed of Peganum harmala by bromophenol blue colorimetry, Zhongcaoyao (2000), 31(9), 660-663.
41 Zhang, Zhenxue; Yao, Xinsheng, Advance of chemical study on medicinal plant Valeriana officinalis L., Zhongguo Yaowu Huaxue Zazhi (2000), 10(3), 226-230.
42 Cheng, Xiujuan; Wang, Naili; Wu, Bo; Wang, Minwei; Yao, Xinsheng, Selected effective prescription of Gualouxiebai-baijiu-tang on myocardial anoxia and ischemia in rodents, Shenyang Yaoke Daxue Xuebao  (2000), 17(5), 375-377.
43 Hu, Ke; Kobayashi, Hisayoshi; Dong, Aijun; Iwasaki, Shigeo; Yao, Xinsheng, Antifungal, antimitotic and anti-HIV-1 agents from the roots of Wikstroemia indica, Planta Med. (2000), 66(6), 564-567.
44 Liu, Dailin; Ma, Jie; Qu, Gexia; Wang, Naili; Yao, Xinsheng, Determination of furostanol saponins in Allium macrostemon, Zhongguo Zhongyao Zazhi  (2000), 25(6), 357-359.
45 Zhang, Zhenxue; Yao, Xinsheng, Development and advances in study on bioactivity for medicinal plant Valeriana officinalis, Shenyang Yaoke Daxue Xuebao  (2000), 17(3), 222-225.
46Liu, Dailin; Liu, Ailing; Qu, Gexia; Wang, Naili; Yao, Xinsheng, Determination of adenosine in Allium macrostemon Bunge of different producing areas and different collecting time, Shenyang Yaoke Daxue Xuebao  (2000), 17(3), 184-187.
47 Zhang Y W; Morita I; Zhang L; Shao G; Yao X S; Murota S., Screening of anti-hypoxia/reoxygenation agents by an in vitro method. Part 2: Inhibition of tyrosine kinase activation prevented hypoxia/reoxygenation-induced injury in endothelial gap junctional intercellular communication, PLANTA MEDICA  (2000 Mar), 66(2), 119-23.
48 Zhang Y W; Morita I; Shao G; Yao X S; Murota S., Screening of anti-hypoxia/reoxygenation agents by an in vitro model. Part 1: Natural inhibitors for protein tyrosine kinase activated by hypoxia/reoxygenation in cultured human umbilical vein endothelial cells, PLANTA MEDICA  (2000 Mar), 66(2), 114-8.
49赵峰,室田诚逸,森田育男,姚新生,抗氧化剂对牛主动脉内皮细胞NF-kB激活的抑制作用,生物化学与生物物理学报,2000,32(4):342-346
50 Masaki Baba, Masayoshi Ohmura(Nee Matsuda), Naoki Kishi, Yoshihito Okada, Shoji Shibata, Jeng Peng, Shin-sen Yao, Hoyoku Nishino and Toru Okuyama, Saponins Isolated from Allium chinense G.Don and Antitumor-promoting Activities of Isoliquiritigenin and Laxogenin from the Same Drug, Biol. Pharm. Bull. 23(5)660-662(2000)
 
专利情况
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荣誉称号和奖励
      2000年获香港理工大学杰出学人称号;
      2001年在长春召开的中国科协学术年会上获香港“求是杰出科技成就集体奖”,或奖金10万元港币(已全部捐献给学校作为优秀特困生奖学金);
      2002年获辽宁省优秀专家称号(中共辽宁省委员会、辽宁省人民政府,2002.4.5)。
主要社会兼职
    深圳中药天然药物研究中心主任;
    沈阳药科大学学术委员会副主任;国际学术交流委员会副主任;学位委员会副主任;高级技术职称评定委员会副主任;
    辽宁省科学基金委员会副主任;学位委员会第一届学科评议组成员;
    沈阳市政府科技顾问;
    大连理工大学客座教授(2002.8~ ,)
    山东医学科学院客座教授(2001~  )
    山东大学兼职特聘教授(2001~ )
    华中理工大学同济药学院名誉教授(2002~)
    浙江大学药学院客座教授(2001~)
    上海医药工业研究院客座教授(上海,2001.2~)
    浙江中医学院顾问及客座教授(杭州,2001.7~)
    台湾中国医药学院荣誉教授(台中,2000.10~)
    日本国九州大学客座教授(福岗,2000.10.1~2001.9.30)
    新药研究国家重点实验室学术委员(2002~);
    生命有机化学国家重点实验室第三届学术委员(2000.10~ );
    植物化学与西部地区植物可持续利用国家重点实验室学术委员(2002~ );
    天然药物与仿生药物国家重点实验室学术委员;
    生物医药国家重点实验室学术委员(2002~);
    深圳中药天然药物研究中心主任(2001.7~)
    中科院大连化物所生物技术研究部首届学术委员会委员(2002.8~ )
    香港理工大学药物研究及现代中药研究所顾问委员会委员(2002.4~2005.4);
    国家中医药管理局《中药资源利用与保护研究中心》重点实验室学术委员(1996~)
    北京大学中医药现代研究中心学术委员会委员(2001.2~,);
    国务院学位委员会药学学科评审组召集人;
    全国博士后管委会医学专家二组副召集人;
    国家自然科学基金委国家杰出青年基金评审委员会委(1995-2002);
    国家新药研究与开发专家委员会第二届委员(国家新药研究与开发领导小组,1998.1~)
    国家药典委员会委员(2002~);
    国家新药评审专家;
    国家自然科学基金委员会第六届、第七届学科评审组成员(1996.5~2000);
    中国药学会副理事长(2002.5~);
    中国执业药师协会常务理事(2003.2~);
    中国辽宁省科学技术协会副理事长(1998~2002)、荣誉会员(2002.6);
    中国化学制药工业协会理事;
    中国科学技术发展基金会药学发展基金委员会理事;
    香港大学基金委员会(University Grants Committee,UGC)优先领域(Area of Excellence,AoE)联合管理局(Consortium Management  Bord)科学顾问(2002.);
    日本汉方药研究振兴财团评议员(2002-);
    现代化中医药国际协会学术顾问(2000.12~,)
   《Journal of Asian Natural Products》编委;
   《中国药物化学》杂志副主编;
   《世界科学技术:中药现代化》杂志编委(科技部主管); 《医药世界》专家委员会委员;
   《中国处方药杂志》编委(国家药品监督局主管);
   《中国中药杂志》编委会副主编;
     通化市政府科学顾问(2001~   ),
     成都市政府科技顾问(2002.11~);
     桂林市政府科技顾问(2002.12~);
     国家中药现代化工程技术研究中心学术委员会副主任(,2001.1~);
     国家中成药工程技术研究中心学术委员会主任
     同仁堂发展专家委员会委员(1999.2~);
     微芯生物技术公司科学顾问(2002.4~),
    上海实业公司科学顾问(2000~),
    重庆市中药研究院名誉研究员(2001.5~)


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