长江学者

郑利民
来源: 日期:2013-07-10 16 【字体:

    郑利民,1984年毕业于上海医科大学后在附属华山医院任临床医生,94年获荷兰莱顿(Leiden)大学细胞生物和免疫学博士学位,1999年获瑞典国家研究院人才基金(助理教授)资助而在瑞典林雪平大学建立了独立的实验室。2002年被聘为中山大学教授,博士导师。2008年度长江学者特聘教授。现任中山大学生命科学院副院长,肿瘤医院兼职教授。2004年获国家杰出青年基金,并担任"973计划"课题组组长。

    郑利民近十余年来一直从事于调控人免疫细胞信号通路的研究,在国际期刊发表论文20篇,总影响因子100余点。目前,主要以人抗原递呈细胞为模型,研究肿瘤逃逸免疫监控的机制和调控人体抗肿瘤免疫应答的关键信号位点,为研制新型防治肿瘤的疫苗和临床药物提供分子水平的基础。同时该模型也可作为观察各种药物对人体免疫功能影响的技术平台。

 

个人简历:

姓名: 郑利民 性别: 男   出生日期: 1964年10月    籍贯: 浙江省

工 作 地 址: 广州中山大学生命科学学院 生物化学系 (邮编:510275)

电 话: 020-84037109 (家); 020-84112163 (办 公 室); 135 3384 9550  

传 真:  020-84112169 E-mail:  Ls110@zsu.edu.cn

目 前 位 置: 中山大学生命科学院 生物化学系 主任;中山大学附属肿瘤医院 教授

研究方向: 1. 肿瘤免疫逃逸机制(以人巨噬细胞为模型);

2. 细胞凋亡的信号通路及凋亡对人体免疫功能的影响。

学 历:

1979.9-1984.7 上海医科大学临床医学系,于1984年7月获医学学士学位。

1985.9-1988.6 上海医科大学研究生院及华山医院,88年6月获医学硕士学位。

1990.1-1994.11荷兰莱顿(Leiden)大学医学院附属医院感染科博士生,

1994年11月通过博士论文答辩,获免疫学和细胞生物博士学位。

工作经历:

1984.9-1990.1 上海医科大学附属华山医院住院医生和总住院医生。

1990.1-1994.11 荷兰莱顿 (Leiden) 大学医学院附属医院感染科博士生。

1994.11-1996.6 瑞典林雪平(Linkoping)大学医学院细胞生物系博士后。

1996.7-1998.12 瑞典隆德(Lund)大学附属马尔墨总医院博士后。

1999.1-2002.8 瑞典林雪平大学助理教授(由瑞典国家医学基金会聘任)。

2002年9月起 广州中山大学生命科学学院教授,博士导师;中山大学附属肿瘤医院兼职教授。

部分论文目录:

1.  L Zheng, PH Nibbering, and R van Furth. 1992. Cytosolic free calcium is required for the IgG-stimulated intracellular killing of Staphylococcus aureus by human monocytes. Infection and Immunity 60:3092-3097.

2.  L Zheng, PH Nibbering, and R van Furth. 1993. Stimulation of the intracellular killing of Staphylococcus aureus by human monocytes mediated by FcγR I and II. European Journal of Immunology 23:2826-2833.

3.  L Zheng, PH Nibbering, TPL Zomerdijk, and R van Furth. 1994 Protein tyrosine kinase activity is essential for the FcγR-stimulated intracellular killing of staphylococcus aureus by human monocytes. Infection and Immunity 62:4296-4303.

4.  L Zheng, TPL Zomerdijk, C Aarnoudse, R van Furth, and PH Nibbering. 1995. Role of protein kinase C isozymes in Fcγ receptor-mediated intracellular killing of S. aureus by human monocytes. The Journal of Immunology 155:776-784.

5.  C Hellberg, L Molony, L Zheng, and T Andersson. 1996. Ca2+ signaling mechanisms of the β2-integrin on neutrophils: involvement of phospholipase Cγ2 and Ins(1,4,5)P3. Biochemical Journal 317:403-409.

6.  E Gronroos, T Andersson, A Schippert, L Zheng, and A Sjolander. 1996. Leukotriene- D4-induced mobilisation of intracellular Ca2+ in epithelial cells is critically dependent on activation of small GTP-binding protein Rho. Biochemical Journal 316:239-245

7.  L Zheng, A Sjolander, J Eckerdal, and T Andersson. 1996. Antibody-induced engagement of β2-integrins in adherent human neutrophils triggers p21ras-activation through tyrosine phosphorylation of the protooncogene product Vav. Proceedings of the National Academy of Sciences of USA 93:8431-8436.

8.  L Zheng, J Eckerdal, I Dimitrijevic, and T Andersson. 1997. Chemotactic peptide-induced activation of Ras in neutrophils is associated with inhibition of p120-GAP activities. The Journal of Biological Chemistry 272:23448-23454.

9.  L Zheng, TPL Zomerdijk, MF Geerstma, R van Furth, and PH Nibbering. 1999. Arachidonic acid, but not its metabolites, mediates the FcγR-stimulated intracellular killing of bacteria by human monocytes. Immunology 96:90-97.

10. N Perskvist, L Zheng, and O Stendahl. 2000. Activation of human neutrophils by mycobacteria tuberculosis H37Ra involves PLCγ2, Shc adaptor protein and p38 MAPK. The Journal of Immunology 164:959-965.

11. L Axelsson, C Hellberg, F Melander, D Smith, L Zheng, and T Andersson. 2000. Clustering of β2 integrins on human neutrophils activates dual signaling pathways to PtdIns 3-kinase. Experimental Cell Research 256:257-263.

12. M Forsberg, R Lofgren, L Zheng, and O Stendahl. 2001. TNFa promotes the CR3-mediated respiratory burst in neutrophil by activating p38 MAPK. Immunology 103:465-472

13. MA Kristensson, MI Porn-Ares, S Grethe, D Smith, L Zheng, and T Andersson. 2002. p38 mitogen-activated protein kinase and PI 3-kinase activities have opposite effects on human neutrophil apoptosis. FASEB Journal. 16:129-131

14. N Perskvist, M Long, O Stendahl and L Zheng. 2002. Mycobacteria tuberculosis promotes apoptosis of human neutrophils by activation of caspase-3 and alteration of Bax/Bcl-xl expression through oxygen-dependent pathways. The Journal of Immunology 168:6358-6365.

15. F Tafazoli, K-E, Magnusson, and L Zheng. 2003. Disruption of epithelial barrier integrity by Salmonella typhimurium requires geranylgeranylated proteins. Infection and Immunity.71:872-881

16. M Forsberg, R Blomgran, M Lerm, E Sarndahl, SM Sebti, A Hamilton, O Stendahl and L Zheng. 2003. Different effect of invasion by and phagocytosis of Salmonella typhimurium on apoptosis in human macrophages-potential role of Rho GTPases and Akt. The Journal of Leukocyte Biology. 74: 620-629

17. M Forsberg, P Druid, L Zheng, O Stendahl and E Sarndahl. 2003. Activation of Rac and Cdc42 upon Fc and complement receptor engagement in human neutrophils. The Journal of Leukocyte Biology. 74: 611-619

18. R Blomgran, L Zheng, and O Stendahl. 2004. Type-1 fimbriated Escherichia coli promote neutrophil apoptosis through an oxygen dependent pathway. Infection and Immunity. 72: 4570-4578

19. L Zheng, M He, M Long, R. Bloomgran, and O Stendahl. 2004. Pathogen-induced apoptotic neutrophils express heat shock proteins and elicit activation of human macrophages. The Journal of Immunology. 173:6319-6326 (中大为第一署名单位)



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